Myasthenia Gravis Holistic Society

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Myasthenia Gravis Holistic Society

Myasthenia Gravis Holistic SocietyMyasthenia Gravis Holistic SocietyMyasthenia Gravis Holistic Society

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  • Myasthenia Gravis
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  • Newly Diagnosed
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  • Holistic Wellness
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  • Resources
  • Vision Board
  • Shop for a cause
  • MG Physicians
  • Caregivers Corner
  • Donate or Join Us
  • Financial Fitness
  • Access & Advocacy
  • DEI
  • Contact Us
  • Members Only
  • Body in Motion
  • Eating to Live
  • In the Garden
  • Hack That MG
  • Relationships
  • Scholarship Form
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Myasthenia Gravis

About Myasthernia Gravis

Video: https://youtu.be/zvx0T4jKdsg

Myasthenia Gravis ( my-us-THEE-nee-uh GRAY-vis) is a rare chronic autoimmune neuromuscular  disease that impacts the voluntary muscles.   Myasthenia Gravis literally means grave muscle weakness.  The first documented case of Myasthenia Gravis was Indian Chief Opechankanough in 1644!  Unlike other diseases we haven’t seen a modern day celebrity come out and say they have myasthenia gravis so you are our celebrity, warriors and heroes. 


Myasthenia Gravis is not contagious.  It is most commonly found in men over 60 and women under 40.  It impacts all ethnic groups however due to health disparities and inequities minorities are delayed in getting diagnosed. Our mission is to change that.  Myasthenia is one of over 7000 rare diseases.  

Checking for MG:

Myasthenia Gravis is most commonly diagnosed my checking for abnormal levels of acetylcholine receptor antibodies (AChR), muscle-specific tyrosine kinase (MuSK) or low-density lipoprotein  receptor related protein 4 (LRP4). 


  Additional testing may be done by checking levels of:

  • Agrin Antibodies (proteoglycan)
  • Collagen Q (ColQ)
  • Collagen XIII
  • Cortactin (cytoplasmic protein)
  • Kv1.4 Antibodies
  • Potassium Channel
  • Rapsyn (intracellular muscle protein)
  • RyR (calcium channel)
  • Striational Antibodies
  • Titin (filamentous intracellular protein)


Double-seronegative Myasthenia Gravis (dSNMG)

There is also a whole community of people who do not have any currently known biomarkers however have all of the classic symptoms of myasthenia gravis.   


A repetitive nerve stimulation or single fiber electromyography (EMG) may be used to detect impaired nerve to muscle transmission may be also considered.  This is an extremely uncomfortable test and hopefully you only have to get it done once.  


 Some cases of MG are diagnosed from having a chest CT or MRI which shows if there is a tumor on the thymus gland called a thymoma.  Don't panic as these tumors are usually non cancerous.  Having this surgery stops the production of autoantibodies that attack the muscle nerve connection.  About 15% of MG patient develop a thymoma.  Surgical intervention may be required.  Weigh your options of technique used.  Ask your doctor to explain transcervical, trans-sternal and videoscope based on your individual case.

 

 Lastly, a neurological examination may reveal decreased muscle strength or impaired eye movement. Some people experience MG only in their eyes while other experience more generalize symptoms.  Track your symptoms to provide your medical team with the best information to help you thrive. 

Symptoms of MG

 People with a diagnosed with Myasthenia Gravis may experience one or more of the symptoms referenced below.  These symptoms may come on all at once or take years to develop.  Some of the symptoms may get better with rest while other symptoms may require medication, immunotherapy, supplements or lifestyle modification.  Each person diagnosed with MG experiences the symptoms differently, this is why it is referred to as the snowflake disease.  We are all very unique in the way MG shows up in our lives.  Additionally, people diagnosed with MG do not all respond the same to the various treatments.  Don't let this discourage you.  Just keep searching to find what works for you.  


Common MG symptoms:

Double vision

Blurred vision

Ptosis (Drooping eyes)

Changes in facial expression 

Difficulty Swallowing

Fatigue

Shortness of breath

Difficulty   chewing

Difficulty walking

Impaired speech

Difficulty smiling

Difficulty talking

Muscle weakness in neck, arms, legs, hands or fingers



Lifestyle changes that help improved MG:

Avoid heat and humidity 

Avoid or proper stress management

Rest and Recover - Allow your body a chance to get the rest it needs

Avoid excessive cold weather




Traditional MG Treatments

MG Holistic Society - Supporting Education

Our organization is committed to supporting education by providing education about the therapies available to people diagnosed with MG.  This list provides a snapshot!


Pyridostigmine (Mestinon)

- Mechanism: Pyridostigmine is an acetylcholinesterase inhibitor that increases the availability of acetylcholine at neuromuscular junctions, improving muscle contraction and strength.

- Administration: Oral, occasionally IV.

- Type of Myasthenia Gravis (MG) Antibodies: Effective in patients with acetylcholine receptor (AChR) antibodies.

- Vaccination Required: None.

- Common Side Effects: Gastrointestinal discomfort, muscle cramps, increased salivation, diarrhea.


Prednisone

- Mechanism: Prednisone is a corticosteroid that reduces inflammation and suppresses the immune system, decreasing the production of antibodies that attack the neuromuscular junction in MG.

- Administration: Oral.

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for both AChR and muscle-specific kinase (MuSK) antibodies.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to the immunosuppressive nature of prednisone.

- Common Side Effects: Weight gain, osteoporosis, hypertension, mood changes, increased risk of infections.


Intravenous Immunoglobulin (IVIG)

- Mechanism: IVIG involves the infusion of pooled immunoglobulin G (IgG) from donors, modulating the immune system by neutralizing autoantibodies and influencing antibody production.

- Administration: Intravenous (IV).

- Type: Immunomodulatory.

- Type of Myasthenia Gravis (MG) Antibodies: Effective in acute exacerbations and crises, regardless of specific antibody type.

- Vaccination Required: None specifically required, but standard vaccinations are advisable.

- Common Side Effects: Headache, fever, chills, flu-like symptoms, allergic reactions.


Azathioprine (Imuran)

- Mechanism: Azathioprine is an immunosuppressant that inhibits purine synthesis, reducing the proliferation of immune cells, particularly lymphocytes.

- Administration: Oral.

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for both AChR and MuSK antibodies.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to immunosuppression.

- Common Side Effects: Nausea, vomiting, leukopenia, hepatotoxicity, increased risk of infections.


Cyclosporine (Neoral, Sandimmune, Gengraf)

- Mechanism: Cyclosporine inhibits calcineurin, essential for T-cell activation, thus reducing the immune response.

- Administration: Oral.

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for both AChR and MuSK antibodies.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to immunosuppression.

- Common Side Effects: Nephrotoxicity, hypertension, tremor, hirsutism, increased risk of infections.


Tacrolimus (Prograf)

- Mechanism: Tacrolimus inhibits calcineurin, similar to cyclosporine, suppressing the immune system.

- Administration: Oral.

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for both AChR and MuSK antibodies.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to immunosuppression.

- Common Side Effects: Nephrotoxicity, neurotoxicity, hyperglycemia, hypertension, increased risk of infections.


Plasmapheresis (PLEX)

- Mechanism: Plasmapheresis involves removing plasma containing autoantibodies from the patient's blood and replacing it with donor plasma or a plasma substitute.

- Administration: Via apheresis (blood purification procedure).

- Type: Immunomodulatory.

- Type of Myasthenia Gravis (MG) Antibodies: Effective in acute exacerbations, regardless of specific antibody type.

- Vaccination Required: None.

- Common Side Effects: Hypotension, infection risk at catheter site, electrolyte imbalances.


Mycophenolate Mofetil (Cellcept)

- Mechanism: Mycophenolate mofetil inhibits inosine monophosphate dehydrogenase, reducing lymphocyte proliferation and antibody production.

- Administration: Oral.

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for both AChR and MuSK antibodies.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to immunosuppression.

- Common Side Effects: Gastrointestinal disturbances, leukopenia, hepatotoxicity, increased risk of infections.


Methotrexate (Xatmep, Otrexup, Rasuvo)

- Mechanism: Methotrexate inhibits dihydrofolate reductase, affecting DNA synthesis and cell replication, particularly in rapidly dividing immune cells.

- Administration: Oral, subcutaneous (Subq), or intramuscular (IM).

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Generally considered for patients who do not respond to other treatments.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to immunosuppression.

- Common Side Effects: Nausea, mucositis, hepatotoxicity, leukopenia, increased risk of infections.


Efgartigimod (Vyvgart/Vyvgart Hytrulo)

- Mechanism: Efgartigimod is a neonatal Fc receptor antagonist that reduces the levels of circulating pathogenic IgG antibodies.

- Administration: Intravenous (IV).

- Type: Biological.

- Type of Myasthenia Gravis (MG) Antibodies: Particularly effective for AChR antibodies.

- Vaccination Required: None specifically required, but standard vaccinations are advisable.

- Common Side Effects: Respiratory tract infections, headache, infusion-related reactions.


Eculizumab (Soliris)

- Mechanism: Eculizumab is a monoclonal antibody that inhibits complement protein C5, preventing the formation of the membrane attack complex.

- Administration: Intravenous (IV).

- Type: Biological.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for AChR antibodies.

- Vaccination Required; Meningococcal vaccination is required before starting treatment due to the increased risk of meningococcal infection.

- Common Side Effects: Respiratory tract infections, headache, infusion-related reactions, increased risk of meningococcal infection.


Ravulizumab (Ultomiris)

- Mechanism: Ravulizumab is similar to eculizumab, targeting complement protein C5 to inhibit the complement cascade.

- Administration: Intravenous (IV).

- Type: Biological.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for AChR antibodies.

- Vaccination Required: Meningococcal vaccination is required before starting treatment due to the increased risk of meningococcal infection.

- Common Side Effects: Upper respiratory tract infections, headache, infusion-related reactions, increased risk of meningococcal infections.


Rozanolixizumab-noli (Rystiggo)

- Mechanism: Rozanolixizumab targets the neonatal Fc receptor, reducing levels of pathogenic IgG antibodies.

- Administration: Subcutaneous (Subq).

- Type: Biological.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for AChR antibodies.

- Vaccination Required: None specifically required, but standard vaccinations are advisable.

- Common Side Effects: Headache, injection site reactions, nausea.


Zilucoplan (Zilbrysq)

- Mechanism: Zilucoplan is a complement C5 inhibitor that prevents the formation of the membrane attack complex.

- Administration: Subcutaneous (Subq).

- Type: Biological.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for AChR antibodies.

- Vaccination Required: None specifically required, but standard vaccinations are advisable.

- Common Side Effects: Injection site reactions, headache, upper respiratory tract infections.


Rituximab (Rituxan)

- Mechanism: Rituximab is a monoclonal antibody that targets CD20 on B-cells, leading to their destruction and reduced antibody production.

- Administration: Intravenous (IV).

- Type: Biological.

- Type of Myasthenia Gravis (MG) Antibodies: Effective for MuSK antibodies and refractory AChR antibodies.

- Vaccination Required: None specifically required, but standard vaccinations are advisable.

- Common Side Effects: Infusion reactions, infections, fatigue.


Cyclophosphamide (Cytoxan)

- Mechanism: Cyclophosphamide is an alkylating agent that interferes with DNA replication, reducing immune cell proliferation.

- Administration: Oral or intravenous (IV).

- Type: Immunosuppressant.

- Type of Myasthenia Gravis (MG) Antibodies: Generally reserved for severe or refractory cases, regardless of specific antibody type.

- Vaccination Required: Annual influenza vaccination and pneumococcal vaccination are recommended due to immunosuppression.

- Common Side Effects: Nausea, vomiting, bone marrow suppression, increased risk of infections, bladder toxicty.


Summary:

The treatments for myasthenia gravis (MG) vary widely in mechanism, administration, and specific antibody efficacy. Common approaches include acetylcholinesterase inhibitors like Pyridostigmine for symptomatic relief, immunosuppressants like Prednisone and Azathioprine for long-term management, and biological therapies such as Eculizumab and Rituximab targeting specific immune pathways. The choice of treatment often depends on the type of MG antibodies present and the severity of the disease. Certain immunosuppressants and biological agents necessitate specific vaccinations, primarily to protect against infections due to immunosuppression or increased susceptibility to particular pathogens.  Treatment specific for seronegative MG people is currently in clinical trials.







We are happy to provide you with the names of new therapies.  Work with your healthcare professionals to decide the best combination of therapies and lifestyle changes needed to help you enjoy a fuller life.  Some of the treatments (complement inhibitor) will require a new series of the meningococcal vaccination even if you have positive titers.   



Our list of alternative therapies have NOT been evaluated by the FDA.  They where selected based on their widely known ability to reduce inflammation. We urge you to discuss these options to enhance your wellness plan with your personal healthcare team. 

Alternative Wellness Options

CBD Oil

CBD oil, derived from the cannabis plant, is gaining attention for its potential health benefits, including for people with myasthenia gravis (MG). Our founder and many others in the MG community use  CBD as part of their wellness journey however it may not work for you.  While research is still ongoing, CBD oil might offer several benefits for those with MG.

Here’s how CBD oil can help people with MG:

1. Reducing Inflammation:

 Inflammation plays a significant role in MG. CBD oil has anti-inflammatory properties that can help reduce inflammation in the body. This might help alleviate muscle weakness and other symptoms associated with MG.

2. Modulating the Immune System:

 CBD interacts with the body’s endocannabinoid system, which plays a role in regulating the immune system. By influencing this system, CBD oil might help balance the immune response, potentially reducing the severity of MG symptoms.

3. Pain Relief:

 Muscle pain and discomfort are common in MG. CBD oil is known for its pain-relieving properties, which might help reduce muscle pain and improve comfort for people with MG.

4. Improving Sleep:

 Many people with MG experience fatigue and sleep disturbances. CBD oil may help improve sleep quality by reducing anxiety and promoting relaxation, which can be beneficial for overall well-being.

5. Anxiety and Stress Reduction:

 Living with a chronic condition like MG can cause anxiety and stress. CBD oil has been shown to help reduce anxiety, which might improve the mental health and quality of life for those with MG.

While studies specific to MG and CBD oil are limited, some research suggests that CBD's anti-inflammatory and immune-modulating effects could be beneficial for autoimmune conditions like MG .

In summary, CBD oil might help people with myasthenia gravis by reducing inflammation, modulating the immune system, relieving pain, improving sleep, and reducing anxiety. However, more research is needed to fully understand its benefits for MG.  Our goal is to be a conduit to make that happen. 

Huperzine A

Huperzine A is a natural compound extracted from the Chinese club moss plant. It's known for its potential benefits in improving memory and cognitive function, but it also has promising effects for people with myasthenia gravis (MG), a condition characterized by muscle weakness and fatigue due to the immune system attacking the connections between nerves and muscles.


Here’s how Huperzine A benefits people with MG:

1. Inhibiting Acetylcholinesterase:

 Huperzine A works by inhibiting an enzyme called acetylcholinesterase. This enzyme breaks down acetylcholine, a neurotransmitter crucial for muscle contraction. By slowing the breakdown of acetylcholine, Huperzine A helps increase its levels in the brain and neuromuscular junctions, improving communication between nerves and muscles.

2. Enhancing Muscle Strength:

 With higher levels of acetylcholine, muscles can contract more effectively. For people with MG, this means better muscle strength and reduced symptoms of muscle weakness, which is a primary challenge of the condition.

3. Neuroprotective Properties:

 Huperzine A also has neuroprotective properties, meaning it helps protect nerve cells from damage. This is important for people with MG, as protecting nerve cells can help maintain proper nerve function and reduce the severity of symptoms.

4. Reducing Fatigue:

 Improved muscle function and better communication between nerves and muscles can help reduce fatigue, a common symptom of MG. This can lead to an overall improvement in daily activities and quality of life.

5. Cognitive Benefits:

 In addition to its effects on muscle strength, Huperzine A is known to enhance cognitive function, which can be beneficial for people with MG who may experience cognitive fatigue.

In summary, Huperzine A benefits people with myasthenia gravis by inhibiting acetylcholinesterase, enhancing muscle strength, protecting nerve cells, reducing fatigue, and improving cognitive function. These effects help alleviate the primary symptoms of MG, leading to a better quality of life for those affected by the condition.  This can be found at health food stores however your personal physician should be consulted prior to starting a new supplement routine.

Nrf2

Nuclear Factor Erythroid 2- Related Factor 2

Nrf2 (Nuclear Factor Erythroid 2–Related Factor 2) is a protein that plays a key role in protecting our cells from damage. It's like a switch that turns on the production of antioxidant and detoxifying enzymes, which help the body fight off stress and harmful substances.

Here’s how Nrf2 benefits people with myasthenia gravis (MG):

1. Protection Against Oxidative Stress:

 Oxidative stress happens when there are too many harmful molecules (free radicals) in the body, which can damage cells. In MG, oxidative stress can make muscle weakness worse. Nrf2 helps activate antioxidants that neutralize these harmful molecules, protecting muscle cells.

2. Reducing Inflammation:

 Inflammation is a big part of MG because the immune system attacks the connections between nerves and muscles. Nrf2 can help reduce inflammation by turning on genes that produce anti-inflammatory proteins. This can ease the symptoms of MG.

3. Improving Muscle Function:

 By reducing oxidative stress and inflammation, Nrf2 helps improve the health of muscles. This can lead to better muscle strength and less fatigue, which are major problems for people with MG.

4. Boosting Cellular Repair:

 Nrf2 also helps activate genes involved in repairing damaged cells. This means it can help the body heal itself more effectively, which is crucial for managing a chronic condition like MG.

5. Enhancing Immune System Balance:

 Nrf2 helps balance the immune system, making it less likely to attack the body’s own tissues. For people with MG, this means less damage to the connections between nerves and muscles.

In summary, Nrf2 helps people with myasthenia gravis by protecting cells from damage, reducing inflammation, improving muscle function, aiding in cellular repair, and balancing the immune system. This leads to better overall health and a reduction in the severity of MG symptoms.  Nrf2 can be purchased a better health food stores.  Work with your personal physician to determine if Nrf2 should be added to your wellness plan. 

Low Dose Naltrexone


Here's how LDN might help people with MG:


1. What is Naltrexone?

 Naltrexone is a drug originally used in higher doses to treat addiction to opioids (like heroin) and alcohol. In low doses, it has different effects that can help with autoimmune diseases like MG.


2. Immune System Modulation:

 MG is an autoimmune disease, meaning the immune system attacks the body's own tissues. LDN is thought to help by modulating, or adjusting, the immune system. Instead of suppressing it completely, LDN gently alters the immune response, reducing the attack on the muscles.


3. Endorphin Boost:

 LDN works by blocking opioid receptors for a short time. This temporary blockage causes the body to produce more endorphins, which are natural chemicals that reduce pain and improve mood. Higher levels of endorphins might help reduce inflammation and autoimmunity, contributing to better muscle function and less fatigue.


4. Reducing Inflammation:

 Chronic inflammation is a big part of autoimmune diseases. By boosting endorphin levels, LDN can help lower inflammation. Less inflammation means the immune system isn't as aggressive in attacking the muscle connections in people with MG.


5. Safety and Tolerability:

 Low-dose naltrexone is generally considered safe and has few side effects. Because it's used in much smaller amounts than when treating addiction, the risk of serious side effects is lower.

6. Symptom Improvement:

 Some people with MG who take LDN report feeling stronger and less tired. They might also have fewer muscle cramps and less difficulty swallowing or breathing. However, it's important to note that while many patients find relief with LDN, it doesn't work for everyone, and it's not a cure for MG.


7. Ongoing Research:

 Scientists are still studying exactly how LDN works and why it helps some people with autoimmune diseases like MG. More research is needed to fully understand its benefits and to determine the best dosage and treatment protocols.

In summary, low-dose naltrexone helps people with myasthenia gravis by modulating the immune system, increasing endorphin levels, and reducing inflammation. This can lead to improved muscle function and less fatigue, offering a better quality of life for those affected by this condition. However, it's not a one-size-fits-all solution, and ongoing research aims to clarify its role in treating MG.  LDN requires a prescription from your (family, internal medicine or neurologist) physician.  A compounding pharmacy usually handles prescriptions of this nature. 

Methylcobalamin

 Methylcobalamin is a form of vitamin B12 that is crucial for nerve health and overall bodily function.

Here’s how methylcobalamin can help people with MG:


1. Supporting Nerve Health:

 Methylcobalamin is particularly important for maintaining healthy nerves. In MG, the communication between nerves and muscles is compromised, leading to muscle weakness. Methylcobalamin helps protect and repair nerve cells, which can improve the transmission of signals between nerves and muscles, potentially reducing muscle weakness.


2. Boosting Energy Levels:

 Vitamin B12 is essential for energy production in the body. People with MG often experience fatigue, which can significantly impact their daily lives. Methylcobalamin helps in the production of energy by aiding in the formation of red blood cells, which carry oxygen throughout the body. This can help reduce fatigue and increase energy levels.


3. Enhancing Cognitive Function:

 Cognitive issues, like brain fog and difficulty concentrating, can occur in people with MG, especially when they are fatigued. Methylcobalamin supports brain health by improving the function of nerve cells in the brain, which can help enhance cognitive function and reduce mental fatigue.


4. Supporting the Immune System:

 Methylcobalamin also plays a role in supporting the immune system. A well-functioning immune system is essential for managing autoimmune conditions like MG. By helping the immune system function more effectively, methylcobalamin can contribute to better overall health.


5. Reducing Homocysteine Levels:

 Elevated levels of homocysteine, an amino acid, can cause damage to blood vessels and nerves. Methylcobalamin helps lower homocysteine levels, which can protect against nerve damage and support cardiovascular health, both of which are important for people with MG.

While specific research on methylcobalamin and MG is limited, studies on its effects on nerve health and energy production suggest it could be beneficial for managing MG symptoms.

In summary, methylcobalamin may help people with myasthenia gravis by supporting nerve health, boosting energy levels, enhancing cognitive function, supporting the immune system, and reducing homocysteine levels. These benefits can contribute to better management of MG symptoms and an improved quality of life.

Vitamin D3

Vitamin D is an essential nutrient that helps our bodies in many ways, including supporting bone health and the immune system. For people with myasthenia gravis (MG), a condition that causes muscle weakness because the immune system attacks the connections between nerves and muscles, vitamin D offers several important benefits.


Here’s how vitamin D can help people with MG:


1. Boosting the Immune System:

 Vitamin D helps regulate the immune system, making it function more effectively. In MG, the immune system mistakenly attacks the body's own tissues. Vitamin D can help calm down this overactive immune response, reducing the severity of symptoms.


2. Reducing Inflammation:

 Inflammation plays a big role in MG. Vitamin D has anti-inflammatory properties, which means it can help lower inflammation in the body. This can lead to less muscle weakness and fatigue.


3. Improving Muscle Strength:

 Vitamin D is crucial for healthy muscles. It helps muscles function properly, which is especially important for people with MG who struggle with muscle weakness. Adequate vitamin D levels can help improve muscle strength and reduce fatigue.


4. Supporting Bone Health:

 People with MG often take medications like steroids that can weaken bones. Vitamin D helps the body absorb calcium, which is essential for strong bones. This can help prevent bone problems that might arise from long-term medication use.


5. Enhancing Overall Health:

 Vitamin D supports overall health and well-being. Feeling healthier overall can help people with MG manage their condition better and improve their quality of life.

In summary, vitamin D helps people with myasthenia gravis by boosting the immune system, reducing inflammation, improving muscle strength, supporting bone health, and enhancing overall health. These benefits can lead to better management of MG symptoms and an improved quality of life.  Get your vitamin D levels checked on a regular basis.  

L-Carnitine

L-carnitine is a nutrient and dietary supplement that plays a key role in energy production by transporting fatty acids into the cells' mitochondria, where they are burned for energy. 


Here’s how L-carnitine can help people with MG:

1. Boosting Energy Levels:


 One of the primary functions of L-carnitine is to help the body produce energy. For people with MG, fatigue is a common and challenging symptom. By improving the efficiency of energy production in cells, L-carnitine can help reduce fatigue and increase overall energy levels, making it easier to manage daily activities.


2. Supporting Muscle Function:

 Muscle weakness is a central issue in MG. L-carnitine helps muscles use fatty acids as an energy source, which can enhance muscle endurance and strength. This could lead to improved muscle function and reduced muscle fatigue for people with MG.


3. Enhancing Exercise Tolerance:

 Exercise can be difficult for those with MG due to fatigue and muscle weakness. L-carnitine has been shown to improve exercise performance by increasing the body’s ability to burn fat for energy and reducing the build-up of lactic acid in muscles, which causes soreness. This can make physical activity more manageable and less exhausting for people with MG.


4. Protecting Against Muscle Damage:

 L-carnitine has antioxidant properties that help protect muscle cells from damage caused by free radicals. By reducing oxidative stress, L-carnitine can help maintain muscle health and prevent further muscle weakening in people with MG.


5. Supporting Heart Health:

 L-carnitine is also beneficial for heart health, which is important for overall well-being. A healthy cardiovascular system supports better circulation and oxygen delivery to muscles, which can help reduce fatigue and improve energy levels in people with MG.

While research specifically on L-carnitine’s effects on MG is limited, studies on its benefits for energy production, muscle function, and exercise performance suggest it could be useful for managing MG symptoms.

In summary, L-carnitine may help people with myasthenia gravis by boosting energy levels, supporting muscle function, enhancing exercise tolerance, protecting against muscle damage, and supporting heart health. These benefits may contribute to better management of MG symptoms and an improved quality of life.

Probiotics and prebiotics

 Probiotics and prebiotics are gaining attention for their potential health benefits, including for people with myasthenia gravis (MG). Probiotics and prebiotics can help improve gut health, which in turn can influence overall health, including immune function.


Here’s how probiotics and prebiotics might help people with MG:


1. Improving Gut Health:

 Probiotics are beneficial bacteria that live in your gut, while prebiotics are fibers that feed these bacteria. A healthy gut microbiome (the community of microorganisms in your gut) is important for overall health. For people with MG, a balanced gut microbiome can help strengthen the body’s defenses and support immune system balance.


2. Modulating the Immune System:

 The gut is closely connected to the immune system. A healthy gut microbiome helps regulate the immune response, making it less likely to attack the body’s own tissues. For people with MG, this could mean a reduction in the severity of symptoms as the immune system becomes more balanced and less prone to overreact.


3. Reducing Inflammation:

 Inflammation is a key factor in MG, contributing to muscle weakness and fatigue. Probiotics and prebiotics can help reduce inflammation by promoting the growth of beneficial bacteria that produce anti-inflammatory compounds. This could help lessen the impact of MG on the body.


4. Enhancing Nutrient Absorption:

 A healthy gut helps the body absorb nutrients more efficiently. For people with MG, better nutrient absorption can support overall health, helping to maintain muscle strength and energy levels, which are often challenged by the condition.


5. Supporting Overall Health:

 Probiotics and prebiotics support digestive health, which is important for overall well-being. Good digestion ensures that the body gets the nutrients it needs, which is crucial for managing chronic conditions like MG.

While research specifically on probiotics and prebiotics for MG is limited, studies show that these supplements can positively influence immune function and inflammation, which are central to managing autoimmune conditions like MG.  Research has shown probiotics ( Bifidobacterium bifidum, Lactobacillus acidophilus, Lactobacillus casei, Lactobacillus reuteri, and Streptococcus thermophilus) may be beneficial for autoimmune dis-ease such as myasthenia gravis.  https://pubmed.ncbi.nlm.nih.gov/23284891/


In summary, probiotics and prebiotics may help people with myasthenia gravis by improving gut health, modulating the immune system, reducing inflammation, enhancing nutrient absorption, and supporting overall health. These benefits could lead to better management of MG symptoms and an improved quality of life.  

Selenium

Selenium is a trace mineral that plays a vital role in various bodily functions, including the immune system and antioxidant defense. 


Here’s how selenium might help people with MG:


1. Antioxidant Protection:

 Selenium is an important component of antioxidant enzymes, such as glutathione peroxidase, which protect cells from oxidative stress. In MG, oxidative stress can worsen muscle weakness and fatigue. By helping to neutralize harmful free radicals, selenium may reduce cellular damage and support muscle health.


2. Immune System Modulation:

 MG is an autoimmune disease, meaning the immune system mistakenly attacks the body's own tissues. Selenium is known to influence the immune system, helping to balance it. This can potentially reduce the immune system's attack on nerve-muscle connections, which may alleviate some of the symptoms of MG.


3. Supporting Thyroid Health:

 Selenium is essential for proper thyroid function. The thyroid gland regulates many processes in the body, including metabolism and energy levels. Maintaining good thyroid health can help improve overall energy levels, which is important for people with MG who often struggle with fatigue.


4. Reducing Inflammation:

 Selenium has anti-inflammatory properties, which can be beneficial for people with MG. Inflammation plays a significant role in the progression of MG symptoms, so reducing inflammation might help lessen muscle weakness and improve overall health.


5. Supporting Overall Health:

 Selenium is involved in various processes that contribute to overall health, including DNA synthesis and reproduction. Maintaining overall health is crucial for people with MG, as it can help manage the condition more effectively.

While research specifically on selenium’s effects on MG is limited, studies on its antioxidant and immune-modulating properties suggest it could be beneficial for people with autoimmune conditions like MG.

In summary, selenium may help people with myasthenia gravis by providing antioxidant protection, modulating the immune system, supporting thyroid and overall health, and reducing inflammation. These benefits could lead to better management of MG symptoms and an improved quality of life.

Irish Sea Moss

 Here’s how Irish Sea Moss can help people with MG:


1. Rich in Nutrients: Irish Sea Moss is packed with vitamins and minerals like vitamin C, vitamin B, iodine, magnesium, and calcium. These nutrients are essential for overall health and can support muscle function and immune system balance.


2. Boosting the Immune System:

 Sea Moss contains nutrients that can help strengthen the immune system. A stronger immune system can help reduce the severity of MG symptoms by making the immune response more balanced and less likely to attack the body's own tissues.


3. Reducing Inflammation:

 Inflammation is a big part of MG. Irish Sea Moss has anti-inflammatory properties, which means it can help lower inflammation in the body. This can lead to less muscle weakness and fatigue, improving overall symptoms.


4. Supporting Digestive Health:

 Irish Sea Moss is a good source of dietary fiber, which supports a healthy digestive system. Good digestion helps ensure that the body absorbs all the necessary nutrients, which is important for maintaining strength and energy levels in people with MG.


5. Enhancing Energy Levels:

 The nutrients in Irish Sea Moss can help boost energy levels. For people with MG, having more energy can make it easier to cope with daily activities and reduce feelings of fatigue.


In summary, Irish Sea Moss helps people with myasthenia gravis by providing essential nutrients, boosting the immune system, reducing inflammation, supporting digestive health, and enhancing energy levels. These benefits may lead to better management of MG symptoms and an improved quality of life.  Most people add sea moss to their smoothies however it can also be taken as supplement. 

Omega -3 Fish Oil

Omega-3 fatty acids are essential fats found in fish oil and some plant oils. They are known for their numerous health benefits, including positive effects for people with myasthenia gravis (MG).


Here's how omega-3s can help people with MG:

1. Reducing Inflammation:

 Omega-3 fatty acids have strong anti-inflammatory properties. Inflammation is a major part of MG, where the immune system mistakenly attacks the body's own tissues. By reducing inflammation, omega-3s can help lessen muscle weakness and other symptoms.


2. Boosting Immune System Balance:

 Omega-3s can help balance the immune system. They make it less likely for the immune system to attack the body's own nerves and muscles. This can reduce the severity of MG symptoms.


3. Improving Muscle Function:

 By reducing inflammation and balancing the immune system, omega-3s help improve overall muscle function. This means people with MG might experience stronger muscles and less fatigue, making it easier to perform daily activities.


4. Supporting Nerve Health:

 Omega-3s also support the health of nerve cells, which is crucial for people with MG. Healthy nerves improve communication between nerves and muscles, helping muscles work better.


5. Enhancing Heart Health:

 People with MG can benefit from the heart health benefits of omega-3s. A healthy heart supports overall health and well-being, which is especially important when managing a chronic condition like MG.

In summary, omega-3 fatty acids help people with myasthenia gravis by reducing inflammation, balancing the immune system, improving muscle function, supporting nerve health, and enhancing heart health. These benefits can lead to better management of MG symptoms and an improved quality of life.  Shop for high quality omega -3 fatty acids supplements.  Foods with omega- fatty acids include: 




Curcumin/ turmeric


Turmeric is a spice that has been used for centuries in traditional medicine, and it’s now gaining attention for its potential health benefits, including for people with myasthenia gravis (MG).  The active ingredient in turmeric, called curcumin, is believed to offer several benefits for people with MG.

Here’s how turmeric might help people with MG:


1. Anti-Inflammatory Properties:

 Inflammation is a major issue in MG, as it contributes to muscle weakness and fatigue. Curcumin, the active compound in turmeric, is a powerful anti-inflammatory agent. It helps reduce inflammation in the body, which can potentially alleviate the symptoms of MG.

2. Antioxidant Effects:

 Turmeric is also known for its antioxidant properties. Oxidative stress, which involves damage to cells by free radicals, can worsen MG symptoms. Curcumin helps neutralize these free radicals, protecting cells and potentially reducing the progression of muscle weakness.


3. Immune System Modulation:

 MG is an autoimmune disease, meaning the immune system mistakenly attacks the body’s own tissues. Curcumin in turmeric has been shown to modulate the immune system, helping to balance it. This could lead to a reduction in the immune system's attack on muscles, easing MG symptoms.


4. Supporting Overall Health:

 Turmeric has been linked to numerous other health benefits, including improved digestion and cardiovascular health. Maintaining overall health is important for people with MG, as it can help manage the condition more effectively.


5. Reducing Fatigue:

 By reducing inflammation and supporting overall health, turmeric may help reduce fatigue, a common and debilitating symptom of MG. This can improve energy levels and quality of life.

While there is limited research specifically on turmeric’s effects on MG, studies on its anti-inflammatory and immune-modulating properties suggest it could be beneficial for people with autoimmune conditions like MG.

In summary, turmeric may help people with myasthenia gravis by reducing inflammation, providing antioxidant protection, modulating the immune system, supporting overall health, and reducing fatigue. These benefits could lead to better management of MG symptoms and an improved quality of life.  When adding turmeric to your cooking remember to add black pepper to activate the Curcumin. Turmeric may also taken in a capsule form. 


These statements have not been reviewed by the FDA.  Check with your wellness provider to decide the best addition to your holistic plan.

DRUG Caution Alert

These drug could be dangerous to your health


Talk to your physician about all medications you are taking. Bring everything you are taking to each appointment with every physician.  Below is a list of drugs that to avoid or use with caution. Your physician will advise you of their safely level.  They could help you avoid a Myasthenia Gravis crisis.


Cautionary drug list: 

Aminoglycosides (antibiotics)

Atenolol (Beta blocker)

Atorvastatin (statin)

Azithromycin (antibiotic)

Botulinum toxin (avoid Botox their commercials advise this as well)

Calcium channel blockers 

Clarithromycin (antibiotic)

Clindamycin (antibiotic)

Chloroquine (antibiotic)

Ciprofloxacin (fluoroquinolones)

Corticosteroids 

D - penicillamine (avoid)

Desferrioxamine

Erythromycin (antibiotic)

Fluoroquinolones (antibiotics)

Gabapentin 

Gentamycin (antibiotic)

Labetalol (Beta blocker)

Iodinated radiology contrast agents

Levofloxacin (fluoroquinolones)

Lidocaine 

Lithium (antipsychotic) 

Neomycin (antibiotic)

Nivolumab 

Magnesium (intravenous)

Metoprolol (Beta blocker)

Moxifloxacin (fluoroquinolones)

Pembrolizumab 

Propanolol (Beta blocker)

Provastatin (cardiovascular)

Procainamide (Antidysrhythmic)

Phenytoin (anti seizure)

Quinine 

Quinidine (cardiovascular)

Rosuvastatin (cardiovascular)

Riluzole 

Simvastatin (cardiovascular)

Timolol (ophthalmic)

Telithromycin (antibiotic)

Tetracycline (antibiotic)

Tobramycin (antibiotic)

Trimethaphan 

Vancomycin (antibiotic)

Verapamil (cardiovascular)

Sources: Medscape, Medline

Downloads

MG Treatments (pdf)Download
MGHS Activity of Holistic Living Survey 3 (pdf)Download
Emergency card 24 - 4x6 (pdf)Download

Copyright © 2024 MG Holistic Society - All Rights Reserved.  Disclaimer: Statements made, or products represented through OUT this website, have not been evaluated by the United States Food and Drug Administration. They are not intended to diagnose, Cure, treat or prevent any disease including myasthenia gravis.  You must consult your personal physician prior to trying anything found on this website. the mg holisitic society, its affliates, volunteers, contributers will not held liable for any damages for any injury resulting from content on this site. 

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